Conférence – Dr Pierre-Luc Boudreault, Thursday, January 23 at 09:00 a.m.

PROTEO is pleased to invite you on Thursday, January 23 at 09:00 a.m. to the presentation by Dr. Pierre-Luc Boudreault (Université de Sherbrooke) invited by Dr. Rafael Najmanovich (Université de Montréal) in the Paul G. Desmarais pavilion, room 1120 – Université de Montréal.

“Peptidomimetics and Macrocycles: Innovative Tools for Targeted Therapies”

Medicinal chemistry, at the intersection of biology and chemistry, is constantly seeking new approaches to develop more effective and targeted therapeutic molecules. One of the most promising emerging strategies is peptidomimetics, which aims to design molecules that mimic or modify the biological activity of natural peptides. These peptidomimetics, while preserving the essence of peptide-receptor interactions, offer pharmacodynamic and pharmacokinetic advantages such as increased affinity and selectivity, improved stability, enhanced bioavailability, and the potential for optimization to cross biological barriers. In this context, the presentation will be divided into two parts: the discovery and development of N-0385, a peptidomimetic transmembrane serine protease type II inhibitor effective against all variants of SARS-CoV-2 and Influenza. The second part will focus on the optimization of a series of macrocycles and peptidomimetic analogs of Apelin-13 and the study of their signaling profiles, leading to potential clinical candidates for the treatment of cardiovascular diseases.

We hope to see many of you there!