- Various research programs are being pursued in the Berghuis lab. However, all programs share a common theme in that they use structural biological approaches to examine interactions between enzymes and small molecules (e.g. substrates, cofactors, inhibitors). The principal technique used for these studies is X-ray crystallography, complemented with small-angle X-ray scattering, electron microscopy, nuclear magnetic resonance spectroscopy, enzymology and computational chemistry tools.
Current Research Projects
- Structural biological studies of anti-microbial resistance mechanisms for advancing new anti-infective therapies.
- Structural biological studies of Bayer-Villigr monooxygenases for green chemistry applications.
Tools and Expertises
- X-ray diffraction/ scattering techniques, enzyme kinetics, computational modeling.