Benoît Vanderperre

Research Interests

• Functional proteomics and genomics, alternative proteins, Parkinson’s disease, mitochondrial metabolism, protein aggregation

Current Research Projects

• Functional study of alternative proteins using CRISPR-Cas9 genome-wide screening
• Molecular and cellular functions of the SLC35A4 double-coding gene in physiological and stress conditions
• In vivo functional study of an alternative protein encoded by the gene ZYX/zyx-1 with implications for muscle and synaptic biology, and dystrophinopathies
• Identification of alternative proteins responsible for selective vulnerability of Adult T-cell Leukemia (ATL) cells using genome-wide CRISPR screening
• Endocytic mechanisms of alpha-synuclein aggregates in iPSC-derived human neural cells
• Role of lysosomal ceramide metabolism in Parkinsons’s disease pathogenesis

Tools and Expertises

• Cultured cells, iPSC-derived human neural cells, lentivirus-mediated expression, CRISPR-Cas9, genome-wide CRISPR-Cas9 screening, organelle-specific proteomics and metabolomics, interactomics (coIP-MS, TurboID, BioID), multi-omics approaches, fluorescence and confocal microscopy.