Research Interests
- Chromatin biology
- Molecular epigenetics
- Gene regulation/transcription
- Genome stability/repair of DNA breaks
- Fusion proteins in cancer
Current Research Projects
- Role of MYST-ING acetyltransferase complexes in transcription regulation, cell fate and disease
- Functional analysis of the NuA4/TIP60 complex in epigenetic mechanisms linked to genome expression and stability
- Defining nucleosome features regulating the function of chromatin modifiers and remodelers
- Understanding the molecular determinants of high-grade endometrial stromal sarcomas
Tools and Expertises
- Biochemistry of protein interactions and with nucleic acids
- Purification of native protein complexes
- Acetylation, methylation of lysines and recognition
- ATP-dependent chromatin remodeling
- Functional genomics (ChIP-seq/RNA-seq/CUtnRUN-seq)
- Genome editing by homologous recombination
- Yeast Saccharomyces cerevisiae
- Mammalian cell culture