Jacques Côté

Research Interests

  • Chromatin biology
  • Molecular epigenetics
  • Gene regulation/transcription
  • Genome stability/repair of DNA breaks
  • Fusion proteins in cancer

Current Research Projects

  • Role of MYST-ING acetyltransferase complexes in transcription regulation, cell fate and disease
  • Functional analysis of the NuA4/TIP60 complex in epigenetic mechanisms linked to genome expression and stability
  • Defining nucleosome features regulating the function of chromatin modifiers and remodelers
  • Understanding the molecular determinants of high-grade endometrial stromal sarcomas

Tools and Expertises

  • Biochemistry of protein interactions and with nucleic acids
  • Purification of native protein complexes
  • Acetylation, methylation of lysines and recognition
  • ATP-dependent chromatin remodeling
  • Functional genomics (ChIP-seq/RNA-seq/CUtnRUN-seq)
  • Genome editing by homologous recombination
  • Yeast Saccharomyces cerevisiae
  • Mammalian cell culture

Our scientific teams