Jean Sévigny

Research Interests

• Functions of extracellular nucleotides with an emphasis on inflammation and inflammatory bowel disease. Focus on intestinal epithelial cells and monocytes/macrophages and neutrophil’s functions. Control of smooth muscle contraction by extracellular nucleotides.

Current Research Projects

• Production of a recombinant soluble form of a protein as a potential treatment for -inflammatory bowel disease (IBD).
• Treatment of IBD with specific antagonists.
• Extracellular nucleotides and pathogenic determinants in inflammation
• Extracellular nucleotides and the control of smooth muscle contraction
• group grant submitted at NIH: “Engineering Human T Regulatory Cells with Chimeric Antigen Receptors Targeting NTPDase3 on the Surface of β cells for Type 1 Diabetes Control.

Tools and Expertises

• cDNA immunisation for polyclonal and monoclonal antibodies.
• Biochemistry and enzymology of ectonucleotidases.
• Pharmacology of nucleotide (P2) receptors.
• Models of inflammation in mice such as DSS, T cell transfer, air pouch.
• Plateform of Ab production :  https://www.crchudequebec.ulaval.ca/services/anticorps/presentation/
• Selling of Abs to ectonucleotidases : http://ectonucleotidases-ab.com