Jean Sévigny

Research Interests

  • Functions of extracellular nucleotides with an emphasis on inflammation and inflammatory bowel disease. Focus on intestinal epithelial cells and monocytes/macrophages and neutrophil’s functions. Control of smooth muscle contraction by extracellular nucleotides.

Current Research Projects

  • Production of a recombinant soluble form of a protein as a potential treatment for -inflammatory bowel disease (IBD).
  • Treatment of IBD with specific antagonists.
  • Extracellular nucleotides and pathogenic determinants in inflammation
  • Extracellular nucleotides and the control of smooth muscle contraction
  • group grant submitted at NIH: “Engineering Human T Regulatory Cells with Chimeric Antigen Receptors Targeting NTPDase3 on the Surface of β cells for Type 1 Diabetes Control.

Tools and Expertises

  • cDNA immunisation for polyclonal and monoclonal antibodies.
  • Biochemistry and enzymology of ectonucleotidases.
  • Pharmacology of nucleotide (P2) receptors.
  • Models of inflammation in mice such as DSS, T cell transfer, air pouch.
  • Plateform of Ab production :
  • Selling of Abs to ectonucleotidases :

Our scientific teams