Jean-Yves Masson

Research Interests

• Molecular mechanisms that repair DNA double-strand breaks (DSBs)
• DNA repair proteins and complexes
• PARP inhibitors
• Functional assays for genetic variants and synthetic lethality
• Genome instability and cancer
• Fanconi Anemia

Current Research Projects

• Defining and targeting the eraser functions of Poly(ADP-ribose) Glycohydrolase (PARG) in PAR-DNA hybrids and DNA double-strand break repair
• Defining the biological consequences of formaldehyde-induced DNA lesions
• Roles of the tumor suppressor PALB2 at the intersection of DNA repair and synthetic lethal strategies in cancer
• Characterization of novel breast cancer susceptibility genes through large-scale targeted sequencing and functional assays.

Tools and Expertises

• Purification of protein complexes
• Protein Biochemistry and Enzymology
• DNA Repair and Recombination Assays
• Genomic and Functional Variant Analysis
• Cellular Imaging
• CRISPR-Cas9 genomic screens