Guy G. Poirier

Research Interests

  • Poly(ADP-ribose) polymerases (PARPs) and poly(ADP-ribosylation)
  • Ovarian cancer
  • PARPs inhibitors
  • DNA damage response and repair mechanism studies

Current Research Projects

  • Study of the role of poly(ADP-ribosylation) in DNA damage response mechanisms
  • Analysis of the role of poly(ADP-ribose) binding proteins in DNA repair by homologous recombination
  • Identification of proteins involved in the mechanisms of sensitivity and resistance to PARP inhibitors
  • Study of the molecular mechanisms involved in the concept of synthetic lethality with PARP inhibitors

Tools and Expertises

  • Mass spectrometry and affinity purification of poly(ADP-ribose) binding protein complexes
  • Confocal microscopy analysis of the localization dynamics of signaling and repair factors to DNA lesions generated by micro-irradiation
  • Synthesis, purification and characterization of poly(ADP-ribose)
  • Identification and characterization of poly(ADP-ribose) binding proteins
  • High throughput cell microscope (Sartorius Incucyte SX5)
  • X-ray irradiation of cells

Our scientific teams