Jacques Côté

Research Interests

• Chromatin biology
• Molecular epigenetics
• Gene regulation/transcription
• Genome stability/repair of DNA breaks
• Fusion proteins in cancer

Current Research Projects

• Role of MYST-ING acetyltransferase complexes in transcription regulation, cell fate and disease
• Functional analysis of the NuA4/TIP60 complex in epigenetic mechanisms linked to genome expression and stability
• Defining nucleosome features regulating the function of chromatin modifiers and remodelers
• Understanding the molecular determinants of high-grade endometrial stromal sarcomas

Tools and Expertises

• Biochemistry of protein interactions and with nucleic acids
• Purification of native protein complexes
• Acetylation, methylation of lysines and recognition
• ATP-dependent chromatin remodeling
• Functional genomics (ChIP-seq/RNA-seq/CUtnRUN-seq)
• Genome editing by homologous recombination
• Yeast Saccharomyces cerevisiae
• Mammalian cell culture