Pierre-Luc Boudreault

Research Interests

• Drug discovery
• Medicinal and peptidomimetic chemistry
• Computer-assisted drug design
• Pharmacology (PK/PD)

Current Research Projects

• Exploring the chemical space of GPCRs (APJr, NTS1/NTS2, AT1r)
• Macrocycle design and synthesis (Protein-protein interactions)
• Novel molecular transporters
• Type 2 Transmembrane Serine Protease inhibitors (TTSPs)
• Emerging class of antibiotics
• Development of resistance-free antivirals
• Design and synthesis of Macrocyclic Epitope Mimics (MEMs) for superior antibody

Tools and Expertises

• Organic, peptide and peptidomimetic synthesis
• Molecular modeling, computer-assisted drug design
• Solid-phase synthesis of chemical libraries
• Pre-clinical evaluation of lead compounds (stability, toxicity, permeability, pharmacokinetics)
• Analysis, characterization, and purification of organic compounds (UPLC-MS, Prep-HPLC-MS, NMR, etc.)