Customized protein databases, functionnal annotation of genomes.
Alternative protein-coding sequences and microproteins.
Current Research Projects
Two main research axes :
Discovery of new proteins (alternative proteins, microproteins) encoded in the genome with the OpenProt proteogenomics ressource, and functional characterization, protein misfolding and neurodegeneration.
Improve the annotation of the coding potential of genomes. Multicoding and polycistronic genes.
Tools and Expertises
Proteogenomics, functional proteogenomics, customized protein databases from RNAseq data, high resolution microscopy, cell biology, prion diseases.